![]() ![]() What is this mark? Is it what I think it is? If so, what does that mean for my pack? This just got a whole lot more complicated. I try to fall asleep but my mind won't turn off. I can't help but smile at how cute she is. I throw the t-shirt back on and climb in. I glance back at the beauty lying in my bed and then back to the mark. It appears to be some sort of light gray vine or flower circling in on itself to form.a heart. There is just enough moonlight peeking in for me to see a mark form on the right side of my chest. I glance over and notice a mirror in the corner of the room but that's not what did it. ![]() I turn to the bed when something catches my eye. I pull off the shirt I threw on when I heard her earlier. I promised I would protect her and protect her I will. I place her back in her bed carefully before going over to the other side. My blood burns at the thought of everything that has happened to her. I scope her fragile body up in my arms and make my way back to the hall. ![]() My heart warms at the comment because I am undoubtedly and irrevocably wrapped around her little finger. Her voice whispers just as she falls asleep. He is my protector who can chase all of the bad away. Even though I haven't known him for that long, I know that he is telling the truth. He hums softly into my hair as my breaths once again even out. "Every time there is thunder or a storm, I will protect you." I think I feel safer in Silas's arms than I have in my entire life. "Aggele mou, that will never happen to you again," Silas declares. He holds me tights and rocks me back and forth until I'm able to calm back down. The tears falling again as a sob breaks free. The storm was so loud, everything was loud. "Aggele mou?" I take a deep breath, breathing in his ocean scent. You have shelter now but you are still afraid." I shake my head pushing back the images that always come when I hear thunder. It's more than just a fear of having no shelter. How could he possibly have guessed that? "You're still shaking every time there is thunder. ![]() "Yeah, but that's not the only reason is it?" I freeze. It was always so loud and bright outside. "Why are you scared of the storm, Aggele mou?" Silas asks. I feel better now about this house but it doesn't stop the anxiety completely. If you were outside you might need to be worried but inside you are safe, okay Aggele mou?" I nod into his chest again. We built this place ourselves so I know how strong it is. "I know it is loud but the thunderstorm cannot harm you in this house. He chuckles a little before holding me tighter. "Aggele mou, you know you can always come to me or any of the others if you're scared or nervous." I nod snuggling back into his chest. I nod sniffling a little as I wipe my cheeks. He pulls me away from him slightly so that we can see each other. I can still hear the thunder going on in the background but it's like Silas has transported me to another world. Nothing's going to harm you here." Slowly my breaths even out as he continues to whisper reassurances to me. I'm so small compared to him, it feels like he is a shield keeping all the bad things away. He pulls me onto his lap and hugs me tightly. "Aggele mou, it's okay,' he states before wrapping his arms around my small body. I jerk my head up, coming face to face with Silas. Why is this happening? I start to see black spots when suddenly a large, warm hands touches my shoulder. "Aggele mou?" the voice calls out closer. "Aggele mou?" I hear a soft voice call out. Why does it have to be so loud? Tears run down my face and quiet sobs escape even as I try to hold them back. I curl up into myself trying to calm the raging storm of fear that is building. Is the house stable enough for this? Do I need to wake the others?Īt these thoughts I try to stand but the trembling of my body has me falling back down. I whimper as the house shakes again due to the loud noise. I dart forward and dive under the table just in time. Another flash of light shines through all of the windows. I dash into the living room, the sound of the rain clearer. Another loud boom sounds, this time closer shaking the entire house. I feel my body start to tremble and can do nothing to stop it. I jump up trying to unwrap myself from the unrelenting covers as quickly as possible. Suddenly a flash of light illuminates the room. ![]()
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![]() ![]() The street style set further proves our point, styling a variety of wedges with slip dresses, white jeans, and even knee-high socks. ![]() Khaite pushed the summery sandal style farther into fall with architectural inverted heels, strapping, and moodier finishes, while Reformation released trendy kitten heel-inspired slingbacks on angular block heels. Bottega Veneta added sleek wedge heels to glossy mules and tall chrome boots, while Ferragamo toyed with the minimal buckles on inverted heels that call back to timeless Mary Jane styles. Function and high fashion fuse together in elevated abstract silhouettes while maintaining hints of classic heel and sandal styles. Something about this season’s reimagined wedge feels chic and sophisticated. While the cork, raffia, and rope wedge heels remain a timeless staple for the summertime, autumnal notes of patent leather, deep hues, metallics, and snakeskin dominated the runways for transitioning season. Forget whatever outdated, early-aughts image pops into your head when you think of wedge sandals, because the comfortable style is officially back - and better than ever.īlock-heeled wedge sandals covered major ground on fall 2023 runways. Some of the most prominent designers of the moment like Bottega Veneta, Loewe, Dior, Alaïa, Ferragamo, and Khaite have introduced updated iterations of the wedge heel in a range of head-turning styles, from dainty sandals, clunky clogs, sleek slingbacks, and minimalist mules. Wedges have emerged as an unexpected breakout trend for fall 2023, as seen on the runways in reinvented silhouettes such as inverted block heels, modern platforms, and architectural curvature. There are so many ways to contextualize the summer staple for the fall, especially as new trends position wedge heels as a contemporary statement for year-round wear. Leather, metallic, or textile finishes on sandal uppers and strapping call for textural styling with slouchy socks, or even juxtaposed with sporty Nike gym socks as an eclectic style statement. They can be worn with anything from long trousers, midi skirts, denim dresses or sweater dresses. When the hot, sunny weather fades to a crisp fall breeze, you can still extend the wear of your stylish and comfortable walking sandal during the transitional months. “Most people prefer wedges for exhibitions, weddings, and vacations because you get that graceful elongated leg without the pain of traditional heels.” Plus, you won’t find yourself sinking into outdoor surfaces like grass, sand, or cobblestone while you’re enjoying your fun in the sun. “In a wedge, the heel is elevated, but the outsole is a continuous solid platform, which allows for increased ankle stability and even weight distribution,” explains Silicon Valley-based podiatrist Najwa Javed. ![]() ![]() Show/hide subitems Explore Document Library Technical resources Application notes Exome data Technical manuals Protocols Certificate of analysis Posters Publications Quick protocols Reading lists Safety data sheets Product data White papers Supporting resources Brochures Selection guides Product inserts Education & Events Show/hide subitems Explore Custom RNA synthesis Antisense oligos Transfection Show/hide subitems Explore Functional Genomic Screening Screening validation and follow-up using engineered cell lines Reverse transfection for high-throughput CRISPR studies C911 controls for siRNA screening Seed sibling controls for RNAi hit validation cDNA/ORF Overexpression Custom RNA synthesis Show/hide subitems Explore Engineered Cell Lines Antibody validation Autophagy pathway Bromodomain containing proteins Caspases Deubiquinating enzymes (DUBs) DNA damage pathways Drug targets Epigenetics Histone acetylation iPSCs Kinase inhibition mTOR pathway Parkinson's disease Phosphoinositide function Phospholipases Primary and stem cells Rab GTPases Serine threonine phosphatase Sialylation pathway Solute carrier slc gene Sumoylation TNF alpha Ubiquitin conjugating enzymes Functional Genomic Screening Show/hide subitems Explore RNA Interference siRNA Self-delivering siRNA shRNA microRNA Noncoding RNA Engineered Cell Lines Show/hide subitems Explore CRISPRmod CRISPR interference CRISPR activation CRISPRa MS2 tracrRNA All-in-one CRISPR modulation RNA Interference Show/hide subitems Explore Gene Editing Engineering a knockout cell line Synthetic sgRNA for CRISPR-Cas9 experiments CRISPR-Cas9 guide RNA algorithm Inducible lentiviral Cas9 nuclease Homology-directed repair with a DNA donor oligo Homology-directed repair with a plasmid donor Multiplex CRISPR-Cas9 knockout All-in-one CRISPR knockout Synthetic lethality CRISPRmod Show/hide subitems Explore Cell Line Engineering Knockout Knock-in Bioproduction cell engineering Pin-point™ Base Editing Services Contract Research Services Custom Reference Standards Custom Oligonucleotides Custom Libraries ![]() Show/hide subitems Explore Cell Panel Screening 2D OncoSignature 2D OncoSignature Long-term assay 3D OncoSignature Custom screens Cell Line Engineering Show/hide subitems Explore Immune Cell Screening CRISPR immune cell screens Custom immune cell screens Compound screening assays iTreg Polarization assay iTreg Suppression assay T Cell Activation assay Mixed Lymphocyte Reaction assay Complement-dependent cytotoxicity assay Cell Panel Screening Show/hide subitems Explore Functional Genomic Screening Arrayed screens Pooled screens CRISPR screens RNAi screens Single-cell CRISPR screens Immune cell screens Pin-point base editing Immune Cell Screening Show/hide subitems Explore Bioproduction Cell Lines CHOSOURCE™ expression platform CHOSOURCE™ TnT transposon technology Transfection & Ancillary Reagents Non-mammalian research Show/hide subitems Explore Downstream Analysis Western blotting supplies Cellular imaging reagents Luminescence assays Fluorescent nucleotides & haptens Microplates Bioproduction Cell Lines Show/hide subitems Explore Libraries CRISPR libraries RNAi libraries Cherry-pick library tool - clones Cherry-pick library tool - synthetic Downstream Analysis Show/hide subitems Explore Reference Standards Create your own reference standard Oncospan Analysis technique Sample type Format Libraries Show/hide subitems Explore Custom Oligonucleotides Single-strand RNA synthesis Custom siRNA Custom antisense oligonucleotides Custom DNA Custom microRNA Reference Standards Show/hide subitems Explore Engineered Cell Models Build your own cell line Knockout cell lines Cancer related cell lines Cas9 stable cell lines dCas9 stable cell lines Custom Oligonucleotides Show/hide subitems Explore Gene Expression CRISPRa cDNA & ORFs Engineered Cell Models ![]() ![]() Show/hide subitems Explore CRISPR Modulation CRISPRi CRISPRa CRISPRa libraries dCas9 stable cell lines Controls Gene Expression Show/hide subitems Explore Gene Knockdown siRNA shRNA microRNA Controls lncRNA Custom siRNA design Cherry-pick library tool - synthetic Cherry-pick library tool - clones RNAi libraries CRISPR Modulation Show/hide subitems Explore Gene Editing CRISPR guide RNA Cas9 nucleases Controls Custom guide RNA Knock-in templates Cherry-pick library tool - clones Cherry-pick library tool - synthetic CRISPR libraries Gene Knockdown Pin-point™ Base Editing Platform All Dharmacon™ Reagents Gene Editing ![]() ![]() ![]() Additional Notes: NOTICE: NVIDIA and INTEL video cards are NOT SUPPORTED to run Mafia III Mac.Processor: Intel Core i5 (4 Cores) 3.2 GHz.NVIDIA GPU: GeForce GTX 780 or GeForce GTX 1060.It contains the main game, all story DLC (Faster, Baby!, Stones Unturned, Sign of the Times) and Bonus Packs (Family Kick-Back Pack and Judge, Jury & Executioner Weapons Pack) bundled in one place for the first time. The Mafia III: Definitive Edition was released on on its own and a part of the Mafia: Trilogy. Mafia III: Official Soundtrack of New Bordeaux - 180 gram audiophile pressing!.Mafia III: Original Game Score - 180 gram audiophile pressing!.Faux Leather Establishment Drink Coasters.The Art of Mafia III Collectible Art Book by Insight Edition. ![]()
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The Stache House Barbershop - Home | The Stache House Barbershop - 170 River Edge Avenue New Milford, New Jersey 07646, (201) 706-0000 The Best 10 Barbers near Dumont, NJ 07628, United States - Yelpīest Barbers in Dumont, NJ 07628, United States - The Spot 201 Barbershop, The Art of Fades Barbershop, Batista Barbershop, The Stache House Barbershop, Kim's Barber Shop, Dominick's Barber Shop, Willow Street Barber Shop, The Shop, Legacy… The Stache House Barbershop - Bergen - New Milford - New. The Art of Fades Barbershop - 37 Foto - Tukang Gunting. Read about places like Tris'barber Shop, The Stache House Barbershop. The Best Barbers in New Milford, NJ on Unilocal. Barbers - New Milford, NJ (United States) 170 River Edge Avenue, New Milford, NJ 07646 +1 20. How Can I Go The Stache House Barbershop? From Where. The Stache House Barbershop Address, phone and customer reviews. ![]() The Stache House Barbershop in New Milford, New Jersey, NJ The stylists at this salon are here to provide. Looking for a good fade? Turn to the barbers at New Milford's The Stache House and receive a one-of-a-kind haircut experience. The Stache House Barbershop - New Milford, NJ | GrouponĪt The Stache House, you can freshen up your look in a flash so schedule your last-minute appointment today. Whether you've got curly, thick hair, or straight thin hair, or a mix of something in between, I know At The Stache House Barber Shop, we welcome our young gentleman (from just months old, to 12 years) to experience any cut of their choice. Home | The Stache House BarbershopĪt The Stache House Barbershop, I've got you covered. Been searching for a reliable barber at a reputable barber shop in town since my old barber moved out of the shop I used to go to. Time zone: Coordinated Universal Time (UTC) for The Stache House Barbershop in New Jersey is -5 hours. The Stache House Barbershop will be closed in 5 hours 41 minutes. The Stache House Barbershop in New Milford City | Explore Before. Being a woman, it's hard to find a barber to do my undercut but haven't had a problem. Best barbershop around! This has been my second time to this barbershop and I've had nothing but a great time. The Stache House Barbershop 170 River Edge Ave New. Being a woman, it's hard to find a barber to do my undercut but haven't had a problem here. ![]() YelpĨ reviews of The Stache House Barbershop "Friendly fun staff. Taxes, fees not included for deals content.The Stache House Barbershop - 55 Photos - Barbers - 170. ![]() ![]() ![]() ![]() With COMSOL 4.4, the Structural Mechanics Module gives you easy access to gravity and Rotordynamic forces, new easier ways to couple shells with solids, as well as a new fast penalty method for mechanical contact. We also have news for our mechanical products in terms of the Heat Transfer Module, there are new tools for modeling bioheating, the thermoelectric effect, and radiation. An Outlet boundary condition is now also available, which will provide much more accurate mass and energy conservation for laminar flow, in addition to convergence that is both quicker and more robust. For instance, a new boundary condition has been included in the CFD Module for the modeling of wall roughness for turbulent flow. ![]() In addition to the new UI, we have made a number of functionality enhancements across the existing products. Functionality Enhancements Across the Product Suite Some other important news items that benefit all users are: a new hover-and-click selection method, auto-complete search tool for variables, user-defined geometric primitives, if/else statements in the model tree for conditional geometry creation, NASTRAN-mesh file export, and time-unit handling in the solvers. If you’re curious as to why we decided to update the UI and what this means for you, check out our previous blog post on the Philosophy of the Ribbon. New UI: Ribbon in COMSOL Multiphysics version 4.4. By only displaying commands when you need them, the ribbon will make it easier for you to find the operations you are looking for to set up your models and run your simulations. We’re very excited to introduce this new UI, as we think it’s going to improve your modeling process by providing a clearer overview of your workflow and just overall being more intuitive to use. So far, the most buzz has been around the updated COMSOL Desktop user interface (UI), with its ribbon design and new Multiphysics node. Today marks the official release of COMSOL Multiphysics version 4.4, and you can now learn about the software updates in detail and download it if you are on subscription. You’ve seen glimpses of our new software release at the COMSOL Conference and perhaps engaged in commentary around it in social media. ![]() ![]() ![]() Buyer will be responsible for all shipping costs for the replacement animal. NO REFUNDS or promises will be issued beyond what has been stated. If a lesser value animal is chosen I will refund the difference to the buyer. In the extreme rare event that the animal(s) do prematurely pass during the approved health guarantee period, I will offer one replacement animal close to or equivalent of equal or lesser value chosen by the buyer. Once the animal leaves my care, I can’t be responsible on how the animal(s) recieves care in its new home. There is no need to offer any greater guarantee as I’ve had the animal(s) for a considerable amount of time (minimum 60 days) & they have thrived. I guarantee the animal(s) for 72 hours with proof of proper husbandry setup & basic care knowledge. BUYER MUST TAKE DELIVERY & INSPECT THE ANIMAL(S) WITHIN SEVENTY FIVE MINUTES OF THE FEDEX HUBS RECEIVED RECIPT & report back to me with proof of time of pick up or alive/arrival & health guarntee are void. NO EXCEPTIONS! This ensures the most safest condition for the animal(s). Animal(s) will be delivered to the buyers nearest FedEx hub. Animal(s) are ALWAYS shipped next day delivery with ALIVE/ARRIVAL GUARANTEE. YOUR animal(s) safety is my HIGHEST PRIORITY. Permitting safe transit & weather conditions from both ends. After payment & buyer confirmation, I will ship out the animal(s) on TUESDAY for WEDNESDAY delivery. I use SHIP YOUR REPTILES who go through FedEx. ![]() All other state deliveries will be $75.00. CA state delivery charge will only be $50.00. PLEASE BE SURE THAT YOU TRULY WANT THE ANIMAL(S) BEFORE COMPLETING THE PURCHASE as all sales are final.Ĭurrently I provide flat rate shipping. If the buyer backs out of the purchase prior to animal(s) being shipped, the paid amount will be refunded but ONLY 70%. After full payment is confirmed, buyer has six hours to respond to my text confirming purchase & shipping date. First one to pay in full will get the animal(s). Animal(s) & all other applicable charges must be paid in full in order to complete sale. If paying using card, an additional 14% will be added to the purchase price for sales tax & card fee. ONLY time trait information will not be shared is if the animal has been listed as PET ONLY or part of a WHOLESALE GROUP sale.ĭebit or Credit cards, Zelle or cash are accepted. I will provide the animal(s) dominant & recessive traits with the leniage knowledge I've obtained from its parent's. I make no guarantee of the animal(s) temperment. THOUGH THE MAJORITY OF THE TIME I WILL BE CORRECT. I make no guarantee as its difficult to ensure a young dragons gender unless 6 months of age or greater. I will sex the animal as best as possible to provide an educated guess of the animal(s) gender. With a proper habitat, food, water, heating, lighting, etc., the animal(s) will resume their natural color & pattern. Note that the animal(s) color & pattern may differ then pictured due to minor stress from shipping & settiling into its new home. It is completely natural for a Bearded Dragon to change over time. I make no guarantee of the animals future coloration or patterns. I make every stride to pictate the animals most current natural color & pattern. ALL photos of the animal(s) are taken by me & are NEVER edited or enhanced. ![]() ![]() Now open up the other side of the pom pom maker and wrap this one until it is full as well.įor this tutorial I’m only using one color, but you could use a different color (or even a few different colors) to make a multicolored pom pom. ![]() Leave the section you just wrapped closed so everything stays secure and get to work on the other side. When the pom pom maker is full you can snip the end of your yarn. When working with the larger size pom pom makers, you will still have a small curve in the middle when the arch is open. If you are having trouble comfortably fitting the arch back into place you may need to unwrap your yarn a bit.Īs you can see in the picture above, it’s very full, but will still fold back into the pom pom maker. If you still have space between the yarn and sides of the pom pom maker, try to wrap it a little more. The best way to check is from time to time, push the yarn-wrapped arch back into place. ![]() I have only used 4 different sizes, but from the ones I’ve tried I find that I need to overfill the smaller ones while the larger ones don’t need to be quite so full. When the side of my pom pom maker is full, it looks like the picture below.įrom my experience, just how full the pom pom maker needs to be is going to depend on which size pom pom maker you are using. It doesn’t really seem to matter whether you wind it section by section or evenly go back and forth until it is full as long as it’s as even as possible.Ĭontinue winding your yarn until it is full. Then begin wrapping your yarn evenly around the curved part. With the Pom Pom Maker already assembled together, open up the “arms” on one side and line them up. Instructions Step 1: Wrap One Side of Pom Pom Makerįor this example, I’m going to be using one of the pom pom makers from the Small set, which makes a finished pom pom about 1 5/8” wide. They are now my dedicated pom pom scissors and I would definitely recommend these to anyone who makes a lot of pom poms like I do. The pointed tip fits easily between the pom pom maker and the spring keeps your hand from getting too tired. So I tried out these scissors and they are absolutely PERFECT for making these types of pom poms. Trimming the pom pom afterward was also very hard on my hands. When I first started using my pom pom makers, I was using a standard pair of scissors and I had a lot of trouble when it came time to snip the yarn loops. But if it has a similar construction to the picture below you should be good to go.Ī quick note about the scissors I use, too. I couldn’t say for sure since I’ve only tried the one brand. I can only imagine that they’d work just as well. If for some reason you are unable to find this particular brand of pom pom maker, I’ve seen others online that look extremely similar. However I plan on buying the extra small and extra large at some point in the future. I own both the small and large sets, which gives me a good standard range of sizes. I think that would cover just about any pom pom project you could dream of. ![]() In total, between all 4 packages there are 7 different sizes that will make poms that range from 3/4” wide to 4.5” wide. They have four different packages with different sizes: Extra Small, Small, Large, and Extra Large (Jumbo). For more information, please see my Disclosure.Īs mentioned above, the brand of pom pom maker that I use is made by Clover. Note: This post may contain affiliate links, which means that if you click on a link and make a purchase, I may earn a small commission at no extra cost to you. So without further ado, let’s get to making some fuzzy little poms! What You Will Need for this Project ![]() But I still keep coming back to these tools because they give me the most fluffy and dense pom poms compared to any other method. There are other ways to make pom poms that also yield great results, which I will have articles for very soon. I have a handful of different methods that I will be posting about over the next week or so, but I’d like to start with my absolute favorite method, which is by using a commercially made pom pom maker, specifically the Clover brand one. So I thought it would be a good idea to write up a few posts on how to make a pom pom. If I CAN make it out of pom poms, I WILL make it out of pom poms!Įven though this blog doesn’t have any pom pom related crafts yet, it definitely will in the near future. From rugs to wreaths to garlands and everything in between. It’s a bit of an understatement to say that I love crafting with pom poms. ![]() ![]() ![]() Have there been any reported FEMA incidents at 3507 Running Deer Dr, Castle Rock, CO? The most recent recorded FEMA incident at 3507 Running Deer Dr, Castle Rock, CO took place in 2003. Is there a record of past sales for the home located at 3507 Running Deer Dr, Castle Rock, CO? The most recent transaction involving a house at 3507 Running Deer Dr, Castle Rock, CO occurred in 2012 year for a price of $414,900. The property features central air conditioning, fireplace and unfinished basement. The property has a masonry facade, attached garage and tile roof on 0.4 acres lot. Last assessment was made in 2014 and makes 41k. What is the architectural style or type of the house located at 3507 Running Deer Dr, Castle Rock, CO? The property located at 3507 Running Deer Dr, Castle Rock, CO is classified as a Single Family Residential residential dwelling. At 3431 Running Deer Dr, Castle Rock, CO there is a property, which was built in 2003. What is the bathroom count in the house located at 3507 Running Deer Dr, Castle Rock, CO? The house situated at 3507 Running Deer Dr, Castle Rock, CO includes a total of 4 baths bathrooms. What is the number of bedrooms in the house located at 3507 Running Deer Dr, Castle Rock, CO? The house situated at 3507 Running Deer Dr, Castle Rock, CO features a total of 4 beds bedrooms. Soaring Eagle Estates is a fantastic neighborhood to be in! The neighborhood has large lots, wide streets, mature landscaping.FAQ When was the house located at 3507 Running Deer Dr, Castle Rock, CO completed? The house situated at 3507 Running Deer Dr, Castle Rock, CO was completed in 2003. Tons of upgrades throughout! New water heater, newer AC, 2 furnaces, 2 AC units, 2 water heaters, updated primary bath, new flooring and more. ![]() From morning's first light to the setting sun, the captivating scenery is the perfect backdrop for your daily life. Most importantly, the stunning views this property offers are truly second to none. Whether you're hosting a summer barbecue, cultivating a home garden, or simply enjoying a morning cup of coffee, the sprawling backyard is your personal oasis with additional room for play structure next to the in ground trampoline. View sales history, tax history, home value estimates, and overhead views. Outside, you'll be captivated by the generous lot size that creates a sense of seclusion and tranquility. house located at 3375 Running Deer Dr, Castle Rock, CO 80109. Addional area can be used for a home gym, game area, or a cozy retreat, the possibilities are endless. It offers ample space with a entertainment area surround sound, a wet bar with two mounted TV’s plus a bar refrigerator. View sales history, tax history, home value estimates, and overhead vie. One of the true gems of this home is the finished walk-out basement. house located at 3502 Running Deer Dr, Castle Rock, CO 80109 sold for 150,000 on Jan 20, 2015. The kitchen flows into a spacious great room with vaulted ceilings, creating a welcoming environment for gatherings and relaxation. Based on Redfin's Castle Rock data, we estimate the home's value is 1,068,082. house located at 3478 Running Deer Dr, Castle Rock, CO 80109 sold for 660,000 on Nov 30, 2017. Each of the five bedrooms exudes its own distinct charm and several offer an en-suite bathroom, providing privacy and a personalized touch. 3507 Running Deer Dr is a 4,209 square foot house on a 0.39 acre lot with 4 bedrooms and 4 bathrooms. As you enter the home, you are greeted by an open and inviting floor plan that flawlessly incorporates a foyer, a well-appointed living room, & a formal dining area. View details, map and photos of this single family property with 4 bedrooms and 3 total baths. COME SEE THE MAKE-OVER PLUS $20,000! TO BUYER AT CLOSING FOR RATE BUY DOWN, UPDATES CLOSING COSTS! New Paint and New appliances! One of a kind location backing to Waverton Ranch w/beautiful views!! 5bed/5bath house in prestigious Soaring Eagle Estates in The Meadows, perfectly situated on an expansive lot that offers breathtaking panoramic views. Sold - 3378 Running Deer Dr, Castle Rock, CO - 920,000. ![]() ![]() Information of the conformational ensembles of molecules extends the 3D-based methods and can be seen as 4D approaches. 3D similarity functions are based on the shape or geometrical distance information of molecules. Those topological or structural fingerprints yield promising results with respect to the enrichment of active molecules, but often lack the ability to discover new chemical entities. MOLPRINT2D, substructure-based fingerprints like BCI and DAYLIGHT as well as the MACCS keys are well known 2D similarity methods. 2D approaches make use of the adjacency matrix of the molecular graph, and, therefore they are also called topological-based approaches. 1D similarity functions are based on molecular property counts such as molecular weight or number of hydrogen bond acceptors. All similarity functions can be categorized by the dimension of the applied representation of molecules. ![]() In the last two decades a plethora of different similarity functions were proposed, and the development of new functions is still an open field of research. Based on the focus on a relevant subset of the database and the possible structural information gain, VS experiments represent a fundamental approach in the drug discovery pipeline. Second, the discovery of new chemical entities that consist of different scaffolds in comparison with the query molecules, and, therefore represent an information gain. First, the enriched molecules should have similar properties as the query molecules. The success of a VS run consists of two different aspects. To ensure the desired properties (e.g., biological activity) and to evaluate the success of the VS run, it is necessary to further analyze the enriched molecules by means of biological assays. The goal of VS is to enrich molecules with similar properties (e.g., biological activity) to the query molecules and to discover new chemical entities in a small fraction of the database. The sorting of such databases, with respect to a given set of queries (molecules) and similarity functions, is known as virtual screening (VS). Sorting and comparing molecules from chemical databases represent two of the key tasks in cheminformatics. With over 100,000 similarity calculations on a single desktop CPU, the utilization of the 4D flexible atom-pair in real-world applications is feasible. Therefore, the weakness of the 3D-based approaches on single conformations is circumvented. The conformational space encoding enables an efficient comparison of the conformational space. Our 4D method yields a robust performance on 40 pharmaceutically relevant targets. As a result, the 4D flexible atom-pair approach achieves an average rank of 1.25 with respect to 15 other state-of-the-art similarity functions and four different evaluation metrics. ![]() ![]() The best 2D- and 3D-based approaches of this study yield an AUC value of 0.74 and 0.72, respectively. The 4D flexible atom-pair method achieves an averaged AUC value of 0.78 on the filtered Directory of Useful Decoys data sets. Even 3D-based approaches that operate on multiple conformers yield inferior results. ResultsĬomparisons of our 4D flexible atom-pair approach with over 15 state-of-the-art 2D- and 3D-based virtual screening similarity functions on the 40 data sets of the Directory of Useful Decoys show a robust performance of our approach. The application of a model-based encoding allows an efficient comparison of the conformational space of compounds. Therefore, we developed a special conformational space encoding by means of Gaussian mixture models and a similarity function that operates on these models. The application of 3D methods on multiple conformer data sets normally reduces this weakness, but entails a significant computational overhead. Therefore, the results of 3D approaches are often less robust than 2D approaches. The performance of 3D-based virtual screening similarity functions is affected by the applied conformations of compounds. ![]() |
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